transforming growth factor, beta receptor III

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NCBI Description of TGFBR3

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Community Annotation of TGFBR3 Add / Edit TGFBR3: Annotations

No community annotations yet for TGFBR3.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TGFBR3 is highly significantly mutated in
TGFBR3 is significantly mutated in
TGFBR3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TGFBR3