TGFA Back

transforming growth factor, alpha

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NCBI Description of TGFA
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TGFA Add / Edit TGFA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TGFA is highly significantly mutated in
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TGFA is significantly mutated in
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TGFA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TGFA