TFR2 Back

transferrin receptor 2

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NCBI Description of TFR2
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of TFR2 Add / Edit TFR2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TFR2 is highly significantly mutated in
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TFR2 is significantly mutated in
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TFR2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TFR2