TFCP2 Back

transcription factor CP2

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NCBI Description of TFCP2
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.

Community Annotation of TFCP2 Add / Edit TFCP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TFCP2 is highly significantly mutated in
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TFCP2 is significantly mutated in
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TFCP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TFCP2