TFB1M Back

transcription factor B1, mitochondrial

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NCBI Description of TFB1M
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of TFB1M Add / Edit TFB1M: Annotations

No community annotations yet for TFB1M.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TFB1M is highly significantly mutated in
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TFB1M is significantly mutated in
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TFB1M is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TFB1M