TFAP4 Back

transcription factor AP-4 (activating enhancer binding protein 4)

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NCBI Description of TFAP4
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TFAP4 is highly significantly mutated in
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TFAP4 is significantly mutated in
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TFAP4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TFAP4