transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

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NCBI Description of TFAP2C

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TFAP2C is highly significantly mutated in
TFAP2C is significantly mutated in
TFAP2C is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TFAP2C