TFAM Back

transcription factor A, mitochondrial

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NCBI Description of TFAM
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.

Community Annotation of TFAM Add / Edit TFAM: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TFAM is highly significantly mutated in
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TFAM is significantly mutated in
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TFAM is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TFAM