TET2 Back

tet oncogene family member 2

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NCBI Description of TET2

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.

Community Annotation of TET2 Add / Edit TET2: Annotations

Added by Tanasan Sirirat



Added by Tanasan Sirirat


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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TET2 is highly significantly mutated in
Acute myeloid leukemia
17 patients (8%)
TET2 is significantly mutated in
TET2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TET2