TERF2 Back

telomeric repeat binding factor 2

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NCBI Description of TERF2
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TERF2 is highly significantly mutated in
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TERF2 is significantly mutated in
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TERF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TERF2