TERF1 Back

telomeric repeat binding factor (NIMA-interacting) 1

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NCBI Description of TERF1

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TERF1 is highly significantly mutated in
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TERF1 is significantly mutated in
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TERF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TERF1