TDP2 Back

tyrosyl-DNA phosphodiesterase 2

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NCBI Description of TDP2

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

Community Annotation of TDP2 Add / Edit TDP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TDP2 is highly significantly mutated in
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TDP2 is significantly mutated in
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TDP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TDP2