TDGF1 Back

teratocarcinoma-derived growth factor 1

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NCBI Description of TDGF1

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.

Community Annotation of TDGF1 Add / Edit TDGF1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TDGF1 is highly significantly mutated in
TDGF1 is significantly mutated in
TDGF1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TDGF1