TCF7L1 Back

transcription factor 7-like 1 (T-cell specific, HMG-box)

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NCBI Description of TCF7L1

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TCF7L1 is highly significantly mutated in
TCF7L1 is significantly mutated in
TCF7L1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TCF7L1