TCF7 Back

transcription factor 7 (T-cell specific, HMG-box)

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NCBI Description of TCF7

The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TCF7 Add / Edit TCF7: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TCF7 is highly significantly mutated in
TCF7 is significantly mutated in
TCF7 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TCF7