TCF12 Back

transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)

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NCBI Description of TCF12
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Community Annotation of TCF12 Add / Edit TCF12: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TCF12 is highly significantly mutated in
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TCF12 is significantly mutated in
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TCF12 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TCF12