TCEB3 Back

transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TCEB3
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

Community Annotation of TCEB3 Add / Edit TCEB3: Annotations

No community annotations yet for TCEB3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TCEB3 is highly significantly mutated in
(none)
TCEB3 is significantly mutated in
(none)
TCEB3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TCEB3