TBX10 Back

T-box 10

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NCBI Description of TBX10
This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate.

Community Annotation of TBX10 Add / Edit TBX10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TBX10 is highly significantly mutated in
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TBX10 is significantly mutated in
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TBX10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TBX10