TBPL1 Back

TBP-like 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TBPL1
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.

Community Annotation of TBPL1 Add / Edit TBPL1: Annotations

No community annotations yet for TBPL1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TBPL1 is highly significantly mutated in
(none)
TBPL1 is significantly mutated in
(none)
TBPL1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TBPL1