TBK1 Back

TANK-binding kinase 1

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NCBI Description of TBK1
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Community Annotation of TBK1 Add / Edit TBK1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TBK1 is highly significantly mutated in
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TBK1 is significantly mutated in
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TBK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TBK1