TAX1BP1 Back

Tax1 (human T-cell leukemia virus type I) binding protein 1

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NCBI Description of TAX1BP1
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TAX1BP1 Add / Edit TAX1BP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TAX1BP1 is highly significantly mutated in
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TAX1BP1 is significantly mutated in
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TAX1BP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TAX1BP1