TAS2R38 Back

taste receptor, type 2, member 38

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TAS2R38

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). Sequence Note: This RefSeq represents the non-taster AVI allele which is defined by polymorphic variation at three positions (A49P, A262V, and V296I).

Community Annotation of TAS2R38 Add / Edit TAS2R38: Annotations

No community annotations yet for TAS2R38.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TAS2R38 is highly significantly mutated in
TAS2R38 is significantly mutated in
TAS2R38 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TAS2R38