TAPT1 Back

transmembrane anterior posterior transformation 1

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NCBI Description of TAPT1
This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined.

Community Annotation of TAPT1 Add / Edit TAPT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TAPT1 is highly significantly mutated in
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TAPT1 is significantly mutated in
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TAPT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TAPT1