TAF8 Back

TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa

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NCBI Description of TAF8
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Community Annotation of TAF8 Add / Edit TAF8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TAF8 is highly significantly mutated in
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TAF8 is significantly mutated in
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TAF8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TAF8