TAF1C Back

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

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NCBI Description of TAF1C
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TAF1C is highly significantly mutated in
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TAF1C is significantly mutated in
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TAF1C is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TAF1C