SYTL4 Back

synaptotagmin-like 4 (granuphilin-a)

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NCBI Description of SYTL4

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.

Community Annotation of SYTL4 Add / Edit SYTL4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SYTL4 is highly significantly mutated in
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SYTL4 is significantly mutated in
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SYTL4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SYTL4