SYTL2 Back

synaptotagmin-like 2

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NCBI Description of SYTL2
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of SYTL2 Add / Edit SYTL2: Annotations

No community annotations yet for SYTL2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SYTL2 is highly significantly mutated in
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SYTL2 is significantly mutated in
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SYTL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SYTL2