SYT1 Back

synaptotagmin I

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NCBI Description of SYT1
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010].

Community Annotation of SYT1 Add / Edit SYT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SYT1 is highly significantly mutated in
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SYT1 is significantly mutated in
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SYT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SYT1