SYNJ2 Back

synaptojanin 2

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NCBI Description of SYNJ2
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.

Community Annotation of SYNJ2 Add / Edit SYNJ2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SYNJ2 is highly significantly mutated in
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SYNJ2 is significantly mutated in
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SYNJ2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SYNJ2