SYNC Back

syncoilin, intermediate filament protein

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NCBI Description of SYNC
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SYNC Add / Edit SYNC: Annotations

No community annotations yet for SYNC.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SYNC is highly significantly mutated in
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SYNC is significantly mutated in
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SYNC is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SYNC