SYMPK Back

symplekin

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SYMPK
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.

Community Annotation of SYMPK Add / Edit SYMPK: Annotations

No community annotations yet for SYMPK.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SYMPK is highly significantly mutated in
(none)
SYMPK is significantly mutated in
(none)
SYMPK is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SYMPK