SUMO4 Back

SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)

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NCBI Description of SUMO4

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.

Community Annotation of SUMO4 Add / Edit SUMO4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SUMO4 is highly significantly mutated in
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SUMO4 is significantly mutated in
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SUMO4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SUMO4