NCBI Description of STXBP5
|Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.|
Community Annotation of STXBP5 Add / Edit STXBP5: Annotations
No community annotations yet for STXBP5.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.