STK39 Back

serine threonine kinase 39 (STE20/SPS1 homolog, yeast)

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NCBI Description of STK39
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

STK39 is highly significantly mutated in
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STK39 is significantly mutated in
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STK39 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for STK39