STK36 Back

serine/threonine kinase 36, fused homolog (Drosophila)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of STK36

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants.

Community Annotation of STK36 Add / Edit STK36: Annotations

No community annotations yet for STK36.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

STK36 is highly significantly mutated in
(none)
STK36 is significantly mutated in
(none)
STK36 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for STK36