NCBI Description of STK19
|This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.|
Community Annotation of STK19 Add / Edit STK19: Annotations
Please see Rodriguez-Martinez M, et al. 2020, Cell 181, 1395–1405, for the corrected annotation: https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930476-1
In the corrected annotation the protein starts at amino acid 111 of the old annotation. Any mutations corresponding to DNA before amino acid 111 are thus in the regulatory region. The recurrent C>T mutation (‘D89N’) does not affect expression of the gene.
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