STAT3 Back

signal transducer and activator of transcription 3 (acute-phase response factor)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of STAT3
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Community Annotation of STAT3 Add / Edit STAT3: Annotations

No community annotations yet for STAT3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

STAT3 is highly significantly mutated in
(none)
STAT3 is significantly mutated in
(none)
STAT3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for STAT3