STARD6 Back

StAR-related lipid transfer (START) domain containing 6

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of STARD6
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008].

Community Annotation of STARD6 Add / Edit STARD6: Annotations

No community annotations yet for STARD6.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

STARD6 is highly significantly mutated in
(none)
STARD6 is significantly mutated in
(none)
STARD6 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for STARD6