NCBI Description of STAM
|This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.|
Community Annotation of STAM Add / Edit STAM: Annotations
No community annotations yet for STAM.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.