ST8SIA1 Back

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

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NCBI Description of ST8SIA1
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of ST8SIA1 Add / Edit ST8SIA1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ST8SIA1 is highly significantly mutated in
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ST8SIA1 is significantly mutated in
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ST8SIA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ST8SIA1