ST14 Back

suppression of tumorigenicity 14 (colon carcinoma)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ST14
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Community Annotation of ST14 Add / Edit ST14: Annotations

No community annotations yet for ST14.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ST14 is highly significantly mutated in
(none)
ST14 is significantly mutated in
(none)
ST14 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ST14