SSPN Back

sarcospan (Kras oncogene-associated gene)

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NCBI Description of SSPN

This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described.

Community Annotation of SSPN Add / Edit SSPN: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SSPN is highly significantly mutated in
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SSPN is significantly mutated in
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SSPN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SSPN