SSH3 Back

slingshot homolog 3 (Drosophila)

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NCBI Description of SSH3
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008].

Community Annotation of SSH3 Add / Edit SSH3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SSH3 is highly significantly mutated in
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SSH3 is significantly mutated in
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SSH3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SSH3