SSB Back

Sjogren syndrome antigen B (autoantigen La)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SSB

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Sequence Note: removed 1 base from the 3' end that did not align to the reference genome assembly.

Community Annotation of SSB Add / Edit SSB: Annotations

No community annotations yet for SSB.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SSB is highly significantly mutated in
SSB is significantly mutated in
SSB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SSB