signal recognition particle receptor, B subunit

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NCBI Description of SRPRB

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.

Community Annotation of SRPRB Add / Edit SRPRB: Annotations

No community annotations yet for SRPRB.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SRPRB is highly significantly mutated in
SRPRB is significantly mutated in
SRPRB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SRPRB