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SFRS protein kinase 1

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NCBI Description of SRPK1

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.

Community Annotation of SRPK1 Add / Edit SRPK1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SRPK1 is highly significantly mutated in
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SRPK1 is significantly mutated in
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SRPK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SRPK1