SRGAP2 Back

SLIT-ROBO Rho GTPase activating protein 2

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NCBI Description of SRGAP2
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SRGAP2 is highly significantly mutated in
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SRGAP2 is significantly mutated in
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SRGAP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SRGAP2