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v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

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NCBI Description of SRC

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Community Annotation of SRC Add / Edit SRC: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SRC is highly significantly mutated in
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SRC is significantly mutated in
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SRC is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SRC