SPZ1 Back

spermatogenic leucine zipper 1

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NCBI Description of SPZ1

This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments.

Community Annotation of SPZ1 Add / Edit SPZ1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SPZ1 is highly significantly mutated in
SPZ1 is significantly mutated in
SPZ1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SPZ1