SPRY4 Back

sprouty homolog 4 (Drosophila)

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NCBI Description of SPRY4
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SPRY4 is highly significantly mutated in
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SPRY4 is significantly mutated in
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SPRY4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SPRY4